StudentShare
Contact Us
Sign In / Sign Up for FREE
Search
Go to advanced search...

Bioinformatics and molecular modelling - Essay Example

Cite this document
Summary
Bioinformatics and Molecular Modelling Name Institution Bioinformatics and Molecular Modelling Part I and II Introduction Lipases are glycerol esters that often act on the triacylglycerols so that they cab release glycerol and acids. The major part of the lipases are used in industrial processes today are stemmed from animal or microbial sources…
Download full paper File format: .doc, available for editing
GRAB THE BEST PAPER96.5% of users find it useful
Bioinformatics and molecular modelling
Read Text Preview

Extract of sample "Bioinformatics and molecular modelling"

Download file to see previous pages

Plant lipases are often considered to be involved in regulating certain plant growths and developments (Bos and Laxminarayan, 2011; 42). They are mainly found in seeds where triglycerides are stored in the form of intracellular structures or the oil bodies. Lipases usually hydrolyze triglycerides to fatty acids and glycerol that produces energy needed for seed germination. The plant lapses are usually classified into three main groups with the first group consisting of the triacylglycerol hydrolases that are mainly found in seeds.

Their study is vital since they are responsible for seed alteration especially during storage. The second group is the acylhydrolases that are found in various plant tissues. They often exhibit limited specificity for their substrates; therefore, they are unable to hydrolyze triglycerides. However, they are cable to catalyze some esterification processes or reactions (Appel and Feytmans, 2009; p. 68). The profound acylhydrolases include phospholipases A and B, sulfolipases, glycolipases, and monoglyceride lipases.

The last group in this category is the phosphorlipases that involve plant metabolism, degradation, and rearrangement. Other than the above classification, the recent studies have led to different classification of lipases based on comparison of the sequences of their amino acid among other fundamental biological and physicochemical properties (Gupta, 2007; 34). This modern classification led to eleven subfamilies. Despite being a member of many protein families, the lipases often have similar architecture that is described by the ?

-hydrolase fold. The activities of all lipases often rely on the catalytic triad that is usually fromed by the Asp, Ser, and His residues. In the sequence of the amino acid especially involving ?/? hydrolases, these three residues often follow the user-Asp-His order. Additionally, lipases often share the consensus sequence defined by the Gly-Xaa-Ser-Xaa-Gly where X may be a residue of an amino acid (Bos and Laxminarayan, 2011; p. 33). The three dimensional structure of any protein molecule often provides valuable insight into the molecular function, organization, docking stimulation, and the effective designing of drug experiments.

The lack of an experimentally determined crystal structure, the homology modeling may be used to provide an opportunity in obtaining a reasonable 3D model. Currently, the 3D models often provide a perfect means of predicting the structure of biomolecules since it yields models that are suitable for a wide application spectrum that are structurally based thereby providing molecular design for mechanism investigation. The 3D approach is capable of providing a reasonable structure model that is often related to template that shares more than 25 percent sequence identity.

An Arabidopsis thaliana lipase model is greatly proposed to investigate the model organism mainly in the plant biology since it is relatively small and and it is genetically tractable genome. Methods The Target and Template Proteins The model is perfect in determining adequate template for the homology modeling for the Arabidopsis thaliana. This sequence allows the alignment of amino acid sequence against the protein data bank (PDB) and this is performed by means of BLAST algorithm. According to the sequence algorithm, both the template (1HLG) and the target share 31 percent of the sequence identity.

...Download file to see next pages Read More
Cite this document
  • APA
  • MLA
  • CHICAGO
(“Bioinformatics and molecular modelling Essay Example | Topics and Well Written Essays - 2000 words”, n.d.)
Retrieved from https://studentshare.org/biology/1466563-bioinformatics-and-molecular-modelling
(Bioinformatics and Molecular Modelling Essay Example | Topics and Well Written Essays - 2000 Words)
https://studentshare.org/biology/1466563-bioinformatics-and-molecular-modelling.
“Bioinformatics and Molecular Modelling Essay Example | Topics and Well Written Essays - 2000 Words”, n.d. https://studentshare.org/biology/1466563-bioinformatics-and-molecular-modelling.
  • Cited: 0 times

CHECK THESE SAMPLES OF Bioinformatics and molecular modelling

Drug Designing with the Aid of Computers

molecular modelling screens through large databases of chemical ligands and molecules of compounds.... molecular imaging has made great revolutions in the designing of drugs.... Tests are carried out for the ‘Lead Compound' Trial conducted in clinics Drug approved Present day drug design extensively relies on computer based molecular modeling techniques.... molecular modeling is a popular method of drug design.... It is a science by means of which molecular structures are represented numerically....
9 Pages (2250 words) Essay

Business Research Applications Paper

Research is in general carried out to look for newer opportunities and to remain in business.... Today we are in an era of globalisation which effectively means all round competition in almost every walk of life.... Pharmaceutical is one such field, which requires research not only to ward off competition but to be relevant with the times....
5 Pages (1250 words) Essay

Does Alcohol dependancy lead to depression

Given the research question, the purpose of the study is to explore four scholarly researches made on the topic identifying methodologies, findings and general… Alcoholism is a form of addiction, a psychological or physiological dependence on alcohol.... It is considered the “third leading preventable cause of death in the United States and is associated with multiple adverse health consequences, including liver cirrhosis, various cancers, unintentional injuries, and violence....
4 Pages (1000 words) Essay

Review of the N314D Point Mutation on the GALT Gene and its Relationship to Galactosemia Type I

Galactosemia type I, also known as classic galactosemia, is a rare, genetic metabolic disorder which follows an autosomal recessive method of inheritance, and affects approximately 1 in 60,000 Caucasian births (Fleisher, 2012).... The deficiency of the enzyme galactose-1-phostpahte… Galactose-1-phostpahte uridyl transferase converts the galactose- 1- phosphate into UDP-galactose....
17 Pages (4250 words) Term Paper

Competitive Inhibitor for Inhibiting the Methylation of Protein Phosphate 2a via LCMT-1

According to Tamanoi and Clarke (2006, p.... 15), PP2A has the role of controlling of cell cycle progression, especially during mitosis phase of the cell.... In their view, little is known concerning the biochemical basis of the regulation of PP2A activity during the cell cycle.... A… tantial amount of PP2A is usually in the methylated form and range from 70 to 93%, which depend of the particular method utilized in the evaluation of the level of methylation....
16 Pages (4000 words) Essay

Bioinformatics amd Molecular Modelling

The author of the "Bioinformatics and molecular modelling" pape examines the Hepatitis C virus and other information that is relevant to bioinformaticians.... It analyses the NS3, protein data bank, the target can website among other issues of molecular biology.... The first to the 3rd genotype prevail more across the world as compared to the rest of HCV genotypes molecular modeling studies are vital in the designing of improved protein inhibitors for the NS3 domain of HCV....
6 Pages (1500 words) Assignment

Bioinformatician in an NHS Clinical Genomics Unit

The report will provide a comprehensive elaboration with the aid of tables and pictures or certificates of the use of cloud computing of bioinformatics and its application in DNA sequencing projects.... This report "Bioinformatician in an NHS Clinical Genomics Unit" provides a description of the cloud computing technology, its features, and types of strategies and how they can be applied in DNA sequencing....
13 Pages (3250 words) Report

Recent Advances in Novel Food Preservation Techniques

… IntroductionFood preservation basically is the exposure of pathogens and spoilage microbes to a hostile environment in order to slow down their growth or shorten their continued existence or cause their instant death.... The reaction of microbes to IntroductionFood preservation basically is the exposure of pathogens and spoilage microbes to a hostile environment in order to slow down their growth or shorten their continued existence or cause their instant death....
18 Pages (4500 words) Assignment
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Contact Us